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| Registros recuperados : 5 | |
| 1. |  | COOK, D.; OLIVEIRA,C.A.; GARDNER, D.R.; PFISTER, J.A; RIET-CORREA, G; RIET-CORREA, F. Changes in swainsonine, calystegine, and nitrogen concentrations on an annual basis in Ipomoea carnea. Toxicon, v. 95, p. 62 - 66, 2015. Article history: Received 31 October 2014.//Received in revised form 31 December 2014.//Accepted 3 January 2015.//Available online 5 January 2015.| Biblioteca(s): INIA La Estanzuela. |
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| 2. | | BURONI, F.; GARDNER, D.R.; BOABAID, F.M.; OLIVEIRA, L.G.S.; DE NAVA, G,; LÓPEZ, F.; RIET-CORREA, F. Spontaneous abortion in cattle after consumption of Hesperocyparis (Cupressus) macrocarpa (Hartw.) Bartel and Cupressus arizonica (Greene) needles in Uruguay. Short communication. Toxicon, 15 July 2020, Volume 181, Pages 53-56. Doi: https://doi.org/10.1016/j.toxicon.2020.04.104 Article history: Received 14 February 2020; Received in revised form 11 April 2020; Accepted 25 April 20; Available online 28 April 2020. Corresponding author: gtdens@adinet.com.uy (G. de Nava), frcorrea@inia.org.uy (F. Riet-Correa)....| Biblioteca(s): INIA Tacuarembó. |
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| 3. | | DE CARVALHO NUNES, L.; STEGELMEIER, B. L.; COOK, D.; PFISTER, J. A.; GARDNER, D. R.; RIET-CORREA, F.; WEICH, K. D. Clinical and pathological comparison of Astragalus lentiginosus and Ipomoea carnea poisoning in goats. Toxicon, 5 December, 2019, Volume 171, Pages 20-28. Doi: 10.1016/j.toxicon.2019.09.016 Article history: Received 12 July 2019; Received in revised form 12 September 2019; Accepted 16 September 2019; Available online 19 September 2019.| Biblioteca(s): INIA Las Brujas. |
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| 4. | | MACHADO, M.; QUEIROZ-MACHADO, C.R.R.; GARDNER, D.R.; CASTRO, M.B.; CÂMARA, A.C.L.; PIMENTEL, L.A.; GALIZA, G.J.N.; RIET-CORREA, F. Leucaena leucocephala toxicity in Brazilian horses. Toxicon. 2024, Volume 240, Article 107655. https://doi.org/10.1016/j.toxicon.2024.107655 Article history: Received 10 January 2024; Received in revised form 16 February 2024; Accepted 18 February 2024; Available online 19 February 2024. -- Correspondence: Machado, M.; Plataforma de Investigación en Salud Animal (PSA),...| Biblioteca(s): INIA Las Brujas. |
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| 5. | | SALINAS, L.M.; BALSEIRO, A.; JIRÓN, W.; PERALTA, A.; MUÑÓZ, D.; FAJARDO, J.; GAYO, E.; MARTÍNEZ, I.Z.; RIET-CORREA, F.; GARDNER, D.R.; GARCÍA MARÍN, J.F. Neurological syndrome in goats associated with Ipomoea trifida and Ipomoea carnea containing calystegines. Toxicon, January 2019, Volume 157, Pages 8-11. Article history: Received 16 September 2018 // Received in revised form 7 November 2018 // Accepted 9 November 2018 // Available online 14 November 2018.
This work was partially supported by a grant from Instituto Nacional de...| Biblioteca(s): INIA Las Brujas. |
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| Registros recuperados : 5 | |
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 | Acceso al texto completo restringido a Biblioteca INIA Las Brujas. Por información adicional contacte bibliolb@inia.org.uy. |
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Registro completo
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Biblioteca (s) : |
INIA Las Brujas. |
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Fecha actual : |
21/01/2020 |
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Actualizado : |
21/01/2020 |
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Tipo de producción científica : |
Artículos en Revistas Indexadas Internacionales |
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Circulación / Nivel : |
Internacional - -- |
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Autor : |
DE CARVALHO NUNES, L.; STEGELMEIER, B. L.; COOK, D.; PFISTER, J. A.; GARDNER, D. R.; RIET-CORREA, F.; WEICH, K. D. |
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Afiliación : |
LOUISIANE DE CARVALHO NUNES, Department of Veterinary Science, Federal University of Espírito Santo, Alegre, Espírito Santo, Brazil; BRYAN L. STEGELMEIER, USDA-ARS Poisonous Plant Research Laboratory, USA; DANIEL COOK, USDA-ARS Poisonous Plant Research Laboratory, USA; JAMES A. PFISTER, USDA-ARS Poisonous Plant Research Laboratory, USA; DALE R. GARDNER, USDA-ARS Poisonous Plant Research Laboratory, USA; FRANKLIN RIET-CORREA AMARAL, INIA (Instituto Nacional de Investigación Agropecuaria), Uruguay; Veterinary Hospital, Center for Health and Rural Technology, Patos Campus, Federal University of Campina Grande, Brazil; KEVIN D. WELCH, USDA-ARS Poisonous Plant Research Laboratory, USA. |
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Título : |
Clinical and pathological comparison of Astragalus lentiginosus and Ipomoea carnea poisoning in goats. |
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Fecha de publicación : |
2019 |
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Fuente / Imprenta : |
Toxicon, 5 December, 2019, Volume 171, Pages 20-28. Doi: 10.1016/j.toxicon.2019.09.016 |
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ISSN : |
0041-0101 |
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DOI : |
10.1016/j.toxicon.2019.09.016 |
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Idioma : |
Inglés |
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Notas : |
Article history: Received 12 July 2019; Received in revised form 12 September 2019; Accepted 16 September 2019; Available online 19 September 2019. |
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Contenido : |
ABSTRACT.
The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic and histochemical studies of the visceral and neurologic lesions observed between goats treated with A. lentiginosus and I. carnea. These findings suggest that I. carnea-induced clinical signs and lesions are due to swainsonine and that calystegines contribute little or nothing to toxicity in goats in the presence of swainsonine.
© 2019 MenosABSTRACT.
The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic a... Presentar Todo |
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Palabras claves : |
Astragalus; Calystegines; Ipomoea; Locoweed; PLATAFORMA SALUD ANIMAL; Swainsonine. |
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Asunto categoría : |
A50 Investigación agraria |
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Marc : |
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260 $c2019
500 $aArticle history: Received 12 July 2019; Received in revised form 12 September 2019; Accepted 16 September 2019; Available online 19 September 2019.
520 $aABSTRACT. The indolizidine alkaloid swainsonine, found in some Astragalus and Oxytropis (i.e., locoweed) species, is a potent cellular glycosidase inhibitor that often poisons livestock. Other toxic genera such as some Ipomoea species also contain swainsonine as well as calystegines which are similar polyhydroxy alkaloids. The toxicity of calystegines is poorly characterized; however, they are also potent glycoside inhibitors capable of intestinal and cellular glycoside dysfunction. The objective of this study was to directly compare A. lentiginosus and I. carnea poisoning in goats to better characterize the role of the calystegines. Three groups of four goats each were treated with ground alfalfa (control), I. carnea or A. lentiginosus to obtain daily doses of 0.0, 1.5, and 1.5 mg swainsonine/kg bw per day, respectively, for 45 days. Animals were observed daily and weekly body weights, serum enzyme activities, and serum swainsonine concentrations were determined. At day 45 all animals were euthanized and necropsied. Goats treated with A. lentiginosus and I. carnea developed clinical disease characterized by mild intention tremors and proprioceptive deficits. Goats treated with A. lentiginosus developed clinical disease sooner and with greater consistency. No differences in body weight, serum swainsonine concentrations and serum enzyme activity were observed between goats treated with A. lentiginosus and I. carnea. Additionally, there were no differences in the microscopic and histochemical studies of the visceral and neurologic lesions observed between goats treated with A. lentiginosus and I. carnea. These findings suggest that I. carnea-induced clinical signs and lesions are due to swainsonine and that calystegines contribute little or nothing to toxicity in goats in the presence of swainsonine. © 2019
653 $aAstragalus
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773 $tToxicon, 5 December, 2019, Volume 171, Pages 20-28. Doi: 10.1016/j.toxicon.2019.09.016
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